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Liver Damage: Rezulin

Liver Damage: Rezulin

Rezulin (troglitazone) is one of several anti-hyperglycemic drugs known as thiazolidinediones. These drugs are insulin-sensitizers that improve insulin sensitivity in skeletal muscle and suppress hepatic glucose output. The only thiazolidinedione available in the United States is troglitazone -of which Rezulin is one type. According to the standard medical text, troglitazone "has potentially idiosyncratic hepatotoxicity."

These drugs have been known to cause of liver damage. Some drugs cause direct toxicity with predictable, dose-related injuries characteristic for the particular drug. Other drugs cause damage only in "susceptible" persons. Such reactions are characterized as idiosyncratic. Through the years, the distinction between the two types of reactions has become less clear. Thus, in situations previously thought to be allergic reactions in susceptible patients, there now appears to be damage directly to cell membranes as a result of drug toxicity.

Different types of drugs can produce a cholestatic reaction. Cholestasis (obstructive jaundice) is a clinical and biochemical syndrome that occurs when bile flow is impaired. This not only induces liver damage but it may even progress to cirrhosis. Click on Cirrhosis, to learn more about this disease.

If you or a loved one has suffered an injury as a result of taking any drug or supplement, call Law Offices of Robert Dourian now at 800-790-8856 or CLICK HERE TO SUBMIT A SIMPLE CASE FORM. The initial consultation is free of charge, and if we agree to review your case, we will work on a contingent fee basis, which means we get paid for our services only if there is a monetary award or recovery of funds. Don't delay! You may have a valid claim and be entitled to compensation for your injuries, but a lawsuit must be filed before the statute of limitations expires.

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